Benzimidazole anthelmintics (Continuation)
CAMBENDAZOLE The most usual application of cambendazole, isopropyl [2-( 4-thiazolyl)-1 H -benzimidazol-5-yl] carbamate, is for treating pig roundworms. ACTIVITY Cambendazole has good roundworm activity and some activity against tapeworms. DOSAGE Horses 20 mg/kg. Sheep 20 mg/kg. Cattle 20 mg/kg. Pigs 20-40 mg /kg. Pigeons 75-150 mg/kg for 2 days. METABOLISM The drug is readily absorbed, but residues prevent treatment of dairy cows. It has a withdrawal period before slaughter of 21 days. TOXICITY Cambendazole is a fairly toxic benzimidazole. It may be lethal to cattle at 2-3 times the recommended dose but sheep tolerate 10 times the dose. The drug may be embryotoxic if dosed to pregnant animals. FLUBENDAZOLE Flubendazole, methyl[5-( 4- fluorobenzoyl)- 1 H-ben zimidazol-2-yl]carbamate, is only used in pig (and human) roundworm therapy. ACTIVITY Fluben