Jagadeeswaran Appusamy

FACTORS ALTERING TOXICITY OF A COMPOUND             For a toxic effect to occur, the toxic agent or its metabolites must reach an appropriate site of action at a sufficient high concentration and for sufficient time to initiate a toxic change. Several factors affect the toxicity of a compound. These are closely related to the factors modifying the drug responses. Toxicosis potential is usually determined more by the multitude of related factors than by actual toxicity of the toxicant. Exposure-related, biologic, or chemical factors regulate absorption, metabolism, and elimination, and thus, influence observed clinical consequences. There are numerous factors which may change response to the toxicants. These factors, either singly or in combination, influence the outcome of toxicity due to a toxicant. These factors can be broadly divided into four major groups: I. Factors related to the toxicant. II. Factors related to the exposure conditions. III. Factors related to the sub

KNOW ABOUT ONE DRUG EVERY DAY FENBENDAZOLE Benzimidazole anthelmintic agent. Type                                        Benzimidazole anthelmintic. Pharmacology & General Information Pharmacology Binds to tubulin, a protein required for functions including nutrient uptake, thus disrupting parasite energy metabolism. Therapeutic Information Uses/Indications Activity Active against adult roundworms and larvae, also kills roundworm eggs (ovicidal). Active against tapeworms. Appropriate Use Dog: used in pregnant and lactating bitches to reduce  roundworms in their puppies. Dog, cat: against lungworm infections.; against some tapeworms. Ruminants: against roundworms, tapeworms. Generally considered safe for use in pregnant animals. Has been used in the treatment of cats, sheep, goats, llamas and pet birds. Indications: UK: " Gastro-intestinal roundworms in horses, ruminants, pigs, dog