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CHOLINERGIC NEUROHUMORAL TRANSMISSION Biosynthesis and Transmission of Acetylcholine   •            acetylcholine is biosynthesized   by the acetylation of choline catalyzed by choline acetyltransferase and acetylcoenzyme A as an acetyl donor •           choline accumulates in axoplasm by uptake process from extraneuronal sites •           ACh accumulates in storage vesicles •           action potential  ------------ influx of Ca 2+   ---------------- release of ACh from vesicles •           ACh in synaptic cleft is rapidly metabolized by acetylcholinesterase Synaptic Transmission at Cholinergic Synapse 1. Synthesis of neurotransmitter - Acetylcholine (ACh) a. Choline transported into presynaptic terminal. Hemicholinium inhibits transport. b. ACh synthesis from choline and acetyl-CoA is catalyzed by choline acetyltransferase (CAT).         Transport and storage of ACh into vesicles in nerve terminal. Vesamicol b